Volume 50 (2004) No. 3-4

Volume 50 (2004) No. 3-4
Dedication to Professor Jan Svoboda, Ph.D., D.Sc.
J. BUBENÍK...................................................77
Full text. 77

Cancer, Infection and Immunity: A Personal Homage to Jan Svoboda*
R. A. WEISS................................................78
Division of Infection and Immunity, University College London, United Kingdom
Corresponding author:  Robin A. Weiss, Division of Infection and Immunity, University College London,
46 Cleveland Street, London W1T 4JF, United Kingdom.  Fax:  +44 (0)20 7679 9555; e-mail: r.weiss@ucl.ac.uk.
*Dedicated to Professor Jan Svoboda on the occasion of his 70th birthday.
Abstract.
Full text. 78-86

Did Viruses Play a Part in the Origin of the Adaptive Immune System?
J. KLEIN......................................................87
Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA, USA
Corresponding author: Jan Klein, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory,
University Park, PA 16802-5301, USA.
No abstract available.
Full text. 87-92

Cell Defence Against Viral/Bacterial Infection: Closer Mechanism than Anticipated?
P. M. PITHA-ROWE....................................93
Sidney Kimmel Comprehensive Cancer Center and Department of Molecular Biology and Genetics, Johns Hopkins University,
Baltimore, Maryland, USA
Corresponding author: Paula M. Pitha-Rowe, Bunting/Blaustein Cancer Research Building, 1650 Orleans Street/Room 351,
Baltimore, MD 21231-1000. Tel.: 410-955-8871; Fax: 410-955-0840; parowe@jhmi.edu.
No abstract available.
Full text. 93-99
Prospects for an Effective T Cell-Based Immunoprophylaxis against Mother-to-Child Transmission of HIV-1
T. HANKE.......................................................100
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford OX3 9DS, United Kingdom
Corresponding author: Tomas Hanke, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford OX3 9DS, United Kingdom. Tel.: +44 1865 222355; Fax: +44 1865 222502; tomas.hanke@imm.ox.ac.uk.
Abstract.
Full text. 100-106

The RCAS Vector System
STEPHEN H. HUGHES....................................107
HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, MD
Corresponding author: Stephen H. Hughes, P.O. Box B, Building 539, Room 130A, Frederick, MD 21702-1201, USA. Tel.:  (301) 846-1619;  Fax:  (301) 846-6966; e-mail:  hughes@ncifcrf.gov.
No abstract available.
Full text. 107-119

Interleukin-2  Therapy of Cancer
J. BUBENÍK......................................................120
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Corresponding author: Jan Bubeník, Institute of Molecular Genetics, Academy of Sciences of  the Czech Republic,
Flemingovo nám. 2, 166 37 Praha 6, Czech Republic, Tel.: +420 220 183 234; Fax: +420 224 310 955; e-mail: bubenik@img.cas.cz.
Abstract.
Full text. 120-130
Non-proliferative Interactions of Epstein-Barr Virus and Human B Lymphocytes
E. KLEIN............................................................131
Microbiology and Tumour Biology Center (MTC), Karolinska Institutet, Stockholm, Sweden
Corresponding author: Eva Klein, Microbiology and Tumour Biology Center (MTC), Karolinska Institutet, Stockholm 171 77,
Sweden; e-mail: Eva.Klein@mtc.ki.se
No abstract available.
Full text. 131-135

Complete Nucleotide Sequences of ALV-Related Endogenous Retroviruses Available from the Draft
Chicken Genome Sequence

L. BORISENKO, A. V. RYNDITCH..........................................136
Corresponding author:  Leonid Borisenko, Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics,
Ukrainian Academy of Sciences, Kiev, Ukraine. Tel.: 038-044-2663498; fax: 038-044-2663498; e-mail: rynditch@imbg.org.ua.
Abstract.
Full text. 136-141

Cancer, Infection and Immunity: A Personal Homage to Jan Svoboda*
R. A. WEISS
Jan Svoboda has had an extraordinary influence on my research.  Following our first meeting in 1967, he encouraged me to pursue
 my tentative evidence for the existence of endogenous retroviruses latent in normal cells.  He introduced me to the Czech scientists,
 Pavel Veselý and Jan Závada, with whom I collaborated fruitfully on the transformed cell phenotype and on virus pseudotypes, respectively.  Through my brief training in his laboratory in Prague I gained a breadth and depth of analysis in virology, immunology and oncology that
helped me subsequently to tackle problems in AIDS and AIDS-associated malignancy at the levels of both cell biology and epidemiology.
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Prospects for an Effective T Cell-Based Immunoprophylaxis against Mother-to-Child Transmission of HIV-1
T. HANKE
Globally, more than 2000 children under 15 years of age are infected with HIV-1 every day. Some of these infections occur in utero, but the majority of children become infected at delivery and after birth through breast-feeding. While success of antiretroviral therapy dramatically decreased mother-to-child transmission in developed countries, antiretroviral drugs are not yet widely available and bottle-feeding is not an option in economically impoverished countries, where burden of HIV-1 infections is the highest. There, effective accessible HIV-1 vaccines limiting spread of HIV-1 in adults and preventing infection of neonates through breast-feeding are urgently needed. For infant vaccines,
given the difficulties in inducing widely cross-reactive HIV-1-neutralizing antibodies, effort has now shifted towards elicitation of cell-mediated immunity, likely in a combination with passively infused neutralizing antibodies and/or chemoprophylaxis. This review discusses prospects
of the T-cell approach for development of a paediatric HIV-1 vaccine.
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Interleukin-2  Therapy of Cancer
J. BUBENÍK
The aim of this review is to evaluate the results of IL-2 therapy of cancer two decades after the first experiments and to discuss whether and which results of local, systemic and adjuvant IL-2 therapy in preclinical models can be translated into clinics. The attention is also focused
on the development and utilization of the IL-2 gene-modified tumour  vaccines for therapeutic purposes. The prospects and limitations
 of both,  IL-2 therapy and IL-2 gene therapy are discussed.
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Complete Nucleotide Sequences of ALV-Related Endogenous Retroviruses Available from the Draft
Chicken Genome Sequence

L. BORISENKO, A. V. RYNDITCH
Complete nucleotide sequences of chicken endogenous retroviruses belonging to E33/E51 and EAV-0 groups have been analysed
on the basis of the recently available draft genome sequence of red jungle fowl (Gallus gallus), the progenitor of domestic chicken (G.g. domesticus). It was shown that all these proviruses have deletions in the SU-coding domain of the env gene, involved in receptor recognition, whereas gag and pol genes appear to be intact. Phylogenetic analysis demonstrated that E33/E51 and EAV-0 groups are related to the
ALV genus. An analysis of expression using chicken EST databases showed that these proviruses are transcriptionally active.
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