Volume 57 (2011) No. 5
Review Article
Chromogranin A in Physiology and Oncology
(chromogranin / neuroendocrine tumours / cleavage fragments / extracellular functions / intracellular functions / tumour marker)
O. LOUTHAN4th Department of Medicine – Department of Gastroenterology and Hepatology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic
Pages: 173 - 181 (PDF)
Corresponding author: Oldřich Louthan, 4th Department of Medicine
– Department of Gastroenterology and Hepatology, First Faculty of Medicine and General University Hospital, Charles University in Prague, U nemocnice 2, 120 00 Prague 2, Czech Republic. e-mail: Louthan@post.cz
Received April 6, 2011. Accepted May 20, 2011.
Original Article
Genetic Variants in Haem Oxygenase-1 and Endothelial Nitric Oxide Synthase Influence the Extent and Evolution of Coronary Artery Atherosclerosis
(endothelial nitric oxide synthase (ENOS) / haem oxygenase-1 (HO-1) / coronary atherosclerosis / plaque burden / plaque composition)
A. KRÁL1, T. KOVÁRNÍK1, L. KRÁLÍK2, H. SKALICKÁ1, J. HORÁK1, G. S. MINTZ3, J. UHROVÁ4, M. SONKA5, A. WAHLE5, R. DOWNE5, M. ASCHERMANN1, P. MARTÁSEK2, A. LINHART1
1Second Department of Medicine – Department of Cardiovascular Medicine, 2Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague and General University
Hospital in Prague, Prague, Czech Republic
3Cardiovascular Research Foundation, New York, NY, USA
4Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
5Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA
Pages: 182 - 190 (PDF)
Corresponding author: Aleš Král, Second Department of Medicine – Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic. Phone: (+420) 224 962 605; Fax: (+420) 224 912 154; e-mail: ales.kral@vfn.cz
Received June 3, 2011. Accepted June 6, 2011.
Original Article
Study of the Effect of Neoadjuvant Chemotherapy on the Status of Her2/neu
(breast cancer / neoadjuvant chemotherapy / Her2/neu / IHC / FISH / real-time PCR)
H. SKÁLOVÁ1, P. DUNDR1, C. POVÝŠIL1, Z. VELENSKÁ1, L. PETRUŽELKA2, D. TVRDÍK1
1Institute of Pathology, 2Department of Oncology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
Pages: 191 - 199 (PDF)
Corresponding author: Daniel Tvrdík, Institute of Pathology, General University Hospital in Prague, Studničkova 2, 128 00 Prague 2, Czech Republic. e-mail: Daniel.Tvrdik@vfn.cz
Received April 1, 2011. Accepted June 16, 2011.
Original Article
Mitoxantrone in Combination with a DNA-PK Inhibitor: Possible Therapy of Promyelocytic Leukaemia Resistant Forms
(HL-60/MX2 / mitoxantrone / double-strand breaks / multiple drug resistance / DNA-PK / NU7026 inhibitor)
V. MIKUSOVÁ1 , A. TICHÝ1 , M. ŘEZÁČOVÁ2, J. VÁVROVÁ1
1Department of Radiobiology, Faculty of Military Health Sciences in Hradec Králové, University of Defence in Brno, Hradec Králové, Czech Republic
2Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
Pages: 200 - 205 (PDF)
Corresponding author: Jiřina Vávrová, Department of Radiobiology, Faculty of Military Health Sciences in Hradec Králové, University of Defence in Brno, Třebešská 1575, 500 01 Hradec Králové, Czech Republic. Phone: (+420) 973 253 214; Fax: (+420) 495 513 018; e-mail: vavrova@pmfhk.cz
Received March 3, 2011. Accepted May 31, 2011.
Original Article
Analysis of Chromosomal Aberrations in Patients with Mental Retardation Using the Array-CGH Technique: a Single Czech Centre Experience
(array-CGH / DNA microarray / mental retardation / chromosomal aberrations)
E. ZRNOVÁ1,2, V. VRANOVÁ1,2, I. SLÁMOVÁ1,2, R. GAILLYOVÁ1, P. KUGLÍK1,2
1University Hospital Brno, Department of Medical Genetics, Integrated Laboratory of Molecular Cytogenetics, Brno, Czech Republic
2Masaryk University, Faculty of Science, Institute of Experimental Biology, Department of Genetics and Molecular Biology, Brno, Czech Republic
Pages: 206 - 215 (PDF)
Corresponding author: Petr Kuglík, Institute of Experimental Biology,
Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno-Bohunice, Czech Republic. Phone: (+ 420) 549 495 439; Fax: (+420) 549 495 071; e-mail: kugl@sci.muni.cz
Received April 18, 2011. Accepted May 20, 2011.
Original Article
Heterochromatin Density (Condensation) During Cell Differentiation and Maturation Using the Human Granulocytic Lineage of Chronic Myeloid Leukaemia as a Convenient Model
(central and peripheral heterochromatin density in situ / cell differentiation and maturation / human leukemic granulocytic lineage)
K. SMETANA, D. MIKULENKOVÁ, H. KLAMOVÁ
Institute of Haematology and Blood Transfusion, Prague, Czech Republic
Pages: 216 - 221 (PDF)
Corresponding author: Karel Smetana, Institute of Haematology
and Blood Transfusion, U nemocnice 1, 128 20 Prague 2, Czech
Republic. e-mail: karel.smetana@uhkt.cz
Received April 6, 2011. Accepted May 16, 2011.
