Volume 58 (2012) No. 3

Review Article

Disseminated and Circulating Tumour Cells and Their Role in Breast Cancer

(breast cancer / detection / disseminated tumour cells / circulating tumour cells / bone marrow / metastasis /
epithelial / mesenchymal transition / cancer stem cells / dormancy / HER2 / prognostic factor)

M. ČABIŇAKOVÁ, P. TESAŘOVÁ

Department of Oncology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic

Pages: 87 - 97 (PDF)

Corresponding author: Michaela Čabiňaková, Department of Oncology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic. Phone: (+420) 224 962 252; Fax: (+420) 224 961 716; e-mail:michaela.cabinakova@vfn.cz

Received December 12, 2011. Accepted December 14, 2011.

Original Article

Activation of the Jak/Stat Signalling Pathway by Leukaemia Inhibitory Factor Stimulates Trans-differentiation of Human Non-Endocrine Pancreatic Cells into Insulin-Producing Cells

(diabetes mellitus / insulin / pancreas / beta cell / islets / stem cells / leukaemia inhibitory factor / differentiation / Notch / Jak/Stat)

T. KOBLAS, I. LEONTOVYČ, K. ZACHAROVOVÁ, Z. BERKOVá, J. Kříž, P. GIRMAN, F. SAUDEK

Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Pages: 98 - 105 (PDF)

Corresponding author: František Saudek, Diabetes Center, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic. Phone: (+420) 261 364 107; e-mail: frsa@medicon.cz

Received November 24, 2011. Accepted December 30, 2011.

Original Article

Xenogeneic Protein-Free Cultivation of Mesenchymal Stromal Cells – Towards Clinical Applications

(BMP / cell therapy / multipotent mesenchymal stromal cells / growth factors / EGF / PDGF / M-CSF / FGF / differentiation / orthopaedic surgery)

D. Stehlík1,2, R. Pytlík3, H. Rychtrmocová3, L. Kideryová3, R. Veselá3, Z. Kopečný1, T. Trč1, M. Trněný3

1Department of Children and Adult Orthopedic Surgery, Second Faculty of Medicine, 2Institute of Anatomy, First Faculty of Medicine, 3First Department of Medicine, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic

Pages: 106 - 114 (PDF)

Corresponding author: David Stehlík, Department of Children and Adult Orthopaedic Surgery, Second Faculty of Medicine, Charles University in P rague, V Úvalu 84, 156 00 P rague 5, Czech R epublic. P hone: (+420) 224 432 801; Fax: (+420) 224 432 820; e-mail: stehlikd@seznam.cz

Received February 13, 2011. Accepted December 27. 2011.

Original Article

Expression of Wnt 3a, β-Catenin, Cyclin D1 and PCNA in Mouse Dentate Gyrus Subgranular Zone (SGZ):  a Possible Role of Wnt Pathway in SGZ Neural Stem Cell Proliferation

(β-catenin / cyclin D1 / subgranular zone / neural stem cell)

D. U. Kumar, H. Devaraj

Unit of Biochemistry, Department of Zoology, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India

Pages: 115 - 120 (PDF)

Corresponding author: Halagowder Devaraj, Unit of Biochemistry, Department of Zoology, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India. Phone: (+91) 44 22202832; Fax: (+91) 44 22301003; e-mail: hdrajum@yahoo.com

Received July 8, 2011. Accepted February 2, 2012.

Original Article

Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy

(MRAS / HNF1A / diabetic nephropathy / type 1 and 2 diabetes)

E. HOROVÁ1, M. PRÁZNÝ1, K. KAŇKOVÁ2, K. BRISMAR3, H. F. GU3

1Third Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic

2Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

3Rolf Luft Center for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden

Pages: 121 - 127 (PDF)

Corresponding author: Eva Horová, Third Department of Internal Medicine, General University Hospital in Prague, U Nemocnice 1, 128 08 Prague 2, Czech Republic. Phone: (+420) 723 846 521; Fax (+420) 224 919 780; e-mail: eva.horova@email.cz

Received November 7, 2011. Accepted March 29, 2012.

Short Communication

Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model

(in vivo fluorescence imaging / mKate2 / glioma growth)

M. Hilšer , J. Trylčová , P. Bušek , A. šedo

Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University in Prague, Czech Republic

Pages: 128 - 133 (PDF)

Corresponding author: Aleksi Šedo, Laboratory of Cancer CellBiology of the Institute of Biochemistry and Experimental Oncology of the First Faculty of Medicine, Charles University in Prague, U Nemocnice 5, 128 53 Prague 2, Czech Republic. e-mail: aleksi@cesnet.cz

Received September 29, 2011. Accepted January 12, 2012.