Volume 58 (2012) No. 5

Original Article

Dynamics and Morphology of Focal Adhesions in Complex 3D Environment

(focal adhesions, 3D, dermis-based matrix, adhesion, migration)

O. Tolde1,3, D. Rösel1, R. Janoštiak1, P. Veselý2, J. Brábek1

1Department of Cell Biology, Faculty of Science, Charles University in Prague, Czech Republic

2CEITEC – Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic

3Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.

Pages: 177 - 184 (PDF)

Corresponding author: Jan Brábek, Department of Cell Biology, Faculty of Science, Charles University in Prague, Viničná 7, 128 43 Prague 2, Czech Republic. Phone: (+420) 22195 1769; Fax: (+420) 22195 1761; e-mail: brabek@natur.cuni.cz

Received May 24, 2012. Accepted June 18, 2012.

Original Article

Low Expression of NQO1 Predicts Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Treated with TAC Regimen

(breast cancer / neoadjuvant therapy / predictive biomarkers)

J. Grim1, P. Jandík3, I. Slánská1, E. Doleželová-Brčáková4, L. Fuksa4, A. Ryška2, J. Knížek5, J. Petera1, S. Mičuda4, H. Hornychová2

1Department of Oncology and Radiotherapy, 2Department of Pathology, 3Department of Surgery, Charles University in Prague, Faculty of Medicine and University Teaching Hospital in Hradec Králové, Czech Republic

4Department of Pharmacology, 5Department of Medical Biophysics, Charles University in Prague, Faculty of Medicine in Hradec Králové, Czech Republic

Pages: 185 - 192 (PDF)

Corresponding author: Jiří Grim, Department of Oncology and Radiotherapy, University Teaching Hospital in Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. Phone: (+420) 495 834 666; e-mail: grimj@lfhk.cuni.cz

Received February 13, 2012. Accepted May 14, 2012.

Original Article

Influence of Platelet γ-Glutamyltransferase on Oxidative Stress and Apoptosis in the Presence of  Holo-Transferrin

(platelet / γ-glutamyltransferase / transferrin / apoptosis / oxidative stress)

A. Sener1, O. Cevik1, G. Yanikkaya- Demirel2, S. Apikoglu-Rabus3, D. Ozsavci1

1Biochemistry Department, 3Clinical Pharmacy Department, Faculty of Pharmacy, Marmara University, Istanbul, Turkey

2Microbiology-Immunology Department, Faculty of Medicine, Yeditepe University, Istanbul, Turkey

Pages: 193 - 202 (PDF)

Corresponding author: Azize Sener, Biochemistry Department, Faculty of Pharmacy, Marmara University, Tibbiye Cad., No. 49, 34668, Haydarpasa-Istanbul, Turkey. e-mail: azizesener@hotmail.com

Received February 13, 2012. Accepted May 13, 2012.

Original Article

Association between a Marker on Chromosome 9 and Acute Coronary Syndrome Confirmatory Study on Czech Population

(acute coronary syndrome / ANRIL / polymorphism / chromosome 9 / CDKN2A / CDKN2B)

J. A. HUBÁČEK1, V. STANĚK1, M. GEBAUEROVÁ1, R. POLEDNE1, M. ASCHERMANN2, H. SKALICKÁ2, J. MATOUŠKOVÁ3, A. KRUGER3, M. PĚNIČKA4, H. HRABÁKOVÁ4, J. VESELKA5, P. HÁJEK5, V. LÁNSKÁ1, V. ADÁMKOVÁ1,6, J. PIŤHA1

1Institute for Clinical and Experimental Medicine, Prague, Czech Republic

22nd Department of Internal Medicine, General University Hospital, Prague, Czech Republic

3Department of Cardiology, Homolka Hospital, Prague, Czech Republic

4Cardiocenter, Department of Cardiology, University Hospital Královské Vinohrady, Prague, Czech  Republic

5Department of Cardiology, Teaching Hospital Motol, Prague, Czech Republic

6University of South Bohemia, Faculty of Health and Social Studies, České Budějovice, Czech Republic

Pages: 203 - 208 (PDF)

Corresponding author: Jaroslav A. Hubáček, IKEM-DEM-LMG, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic. Phone: (+420) 261 363 379; Fax: (+420) 241 721 666; e-mail: jahb@ikem.cz

Received February 13, 2012. Accepted March 15, 2012.

 

Original Article

Transcriptional Activity of Tumour Necrosis Factor α (TNF-α) in Patients with Subclinical Coronary Atherosclerosis – Preliminary Results

(tumour necrosis factor α / subclinical atherosclerosis)

J. Dąbek1, R. Świderski1, J. Głogowska-Ligus2, P. Pysz1

1Department of Cardiology, 2Department of Epidemiology, Medical University of Silesia in Katowice, Poland

Pages: 209 - 214 (PDF)

Corresponding author: Joanna Głogowska-Ligus, Department of Epidemiology, Medical University of Silesia, Piekarska 18, 41-902 Bytom, Poland. Phone: (+48) 32 397 65 31; e-mail: jglogowska@sum.edu.pl

 

Received March 28, 2012. Accepted April 30, 2012.

Short Communication

Testing Chemical Agents with the Cytokinesis-Block Micronucleus Cytome Assay

(C3A cells / genotoxicity / chemical mutagens / spindle poisons / clastogens / enzyme inhibitors)

A. Maes1, R. Anthonissen1, L. Verschaeve1,2

1Scientific Institute of Public Health, O.D. Public Health and Surveillance, Laboratory of Toxicology, Brussels, Belgium

2Department of Biomedical Research, University of Antwerp, Antwerp, Belgium

Pages: 215 - 220 (PDF)

Corresponding author: Luc Verschaeve, Scientific Institute of Public Health, O.D. Public Health and Surveillance, Laboratory of Toxicology, J. Wytsmanstreet 14, B-1050 Brussels, Belgium. Phone: +32 2 642 54 36; Fax: +32 2 642 52 24; e-mail: luc.verschaeve@wiv-isp.be

Received January 4, 2012. Accepted April 2, 2012.