Volume 50 (2004) No. 3-4
Dedication to Professor Jan Svoboda, Ph.D., D.Sc.
Prospects for an Effective T Cell-Based Immunoprophylaxis against Mother-to-Child Transmission of HIV-1
T. HANKE.......................................................100
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford OX3 9DS, United Kingdom
Corresponding author: Tomas Hanke, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford OX3 9DS, United Kingdom. Tel.: +44 1865 222355; Fax: +44 1865 222502; tomas.hanke@imm.ox.ac.uk.
Abstract.
Full text. 100-106
Cancer, Infection and Immunity: A Personal Homage to Jan Svoboda*
R. A. WEISS
Jan Svoboda has had an extraordinary influence on my research. Following our first meeting in 1967, he encouraged me to pursue
my tentative evidence for the existence of endogenous retroviruses latent in normal cells. He introduced me to the Czech scientists,
Pavel Veselý and Jan Závada, with whom I collaborated fruitfully on the transformed cell phenotype and on virus pseudotypes, respectively. Through my brief training in his laboratory in Prague I gained a breadth and depth of analysis in virology, immunology and oncology that
helped me subsequently to tackle problems in AIDS and AIDS-associated malignancy at the levels of both cell biology and epidemiology.
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Prospects for an Effective T Cell-Based Immunoprophylaxis against Mother-to-Child Transmission of HIV-1
T. HANKE
Globally, more than 2000 children under 15 years of age are infected with HIV-1 every day. Some of these infections occur in utero, but the majority of children become infected at delivery and after birth through breast-feeding. While success of antiretroviral therapy dramatically decreased mother-to-child transmission in developed countries, antiretroviral drugs are not yet widely available and bottle-feeding is not an option in economically impoverished countries, where burden of HIV-1 infections is the highest. There, effective accessible HIV-1 vaccines limiting spread of HIV-1 in adults and preventing infection of neonates through breast-feeding are urgently needed. For infant vaccines,
given the difficulties in inducing widely cross-reactive HIV-1-neutralizing antibodies, effort has now shifted towards elicitation of cell-mediated immunity, likely in a combination with passively infused neutralizing antibodies and/or chemoprophylaxis. This review discusses prospects
of the T-cell approach for development of a paediatric HIV-1 vaccine.
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Interleukin-2 Therapy of Cancer
J. BUBENÍK
The aim of this review is to evaluate the results of IL-2 therapy of cancer two decades after the first experiments and to discuss whether and which results of local, systemic and adjuvant IL-2 therapy in preclinical models can be translated into clinics. The attention is also focused
on the development and utilization of the IL-2 gene-modified tumour vaccines for therapeutic purposes. The prospects and limitations
of both, IL-2 therapy and IL-2 gene therapy are discussed.
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Complete Nucleotide Sequences of ALV-Related Endogenous Retroviruses Available from the Draft
Chicken Genome Sequence
L. BORISENKO, A. V. RYNDITCH
Complete nucleotide sequences of chicken endogenous retroviruses belonging to E33/E51 and EAV-0 groups have been analysed
on the basis of the recently available draft genome sequence of red jungle fowl (Gallus gallus), the progenitor of domestic chicken (G.g. domesticus). It was shown that all these proviruses have deletions in the SU-coding domain of the env gene, involved in receptor recognition, whereas gag and pol genes appear to be intact. Phylogenetic analysis demonstrated that E33/E51 and EAV-0 groups are related to the
ALV genus. An analysis of expression using chicken EST databases showed that these proviruses are transcriptionally active.
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