Volume 59 (2013) No. 4

Original Article

The Role of Inflammation in the Progression of Ocular Surface Damage in Children Following Allogeneic Haematopoietic Cell Transplantation

(impression cytology / stem cell allotransplantation / HLA-DR expression / conjunctiva)

M. Kurpińska1, A.Turno-Kręcicka1, H. Zając-Pytrus1, P. Dzięgiel3, M. Misiuk-Hojło1, E. Gorczyńska2

1Department of Ophthalmology, 2Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, 3Department of Histology and Embryology, Wrocław Medical University, Poland.

Pages: 139 - 145 (PDF)

Corresponding author: Małgorzata Kurpińska, Department of Ophthalmology, Wrocław Medical University, ul. Borowska 213, 50-556 Wrocław, Poland. Phone: (+48) 71 736 43 00; Fax: (+48) 71 736 43 09; e-mail: mkurpinska7@wp.pl

 

Original Article

Selective Depletion of Alloreactive Donor T Cells Leads to Elimination of Graft-Versus-Host Reactivity and Stimulates Graft-Versus-Leukaemia/Myeloma Effect

(anti-CD25 immunotoxin / selective depletion / graft-versus-host disease / leukaemia / multiple myeloma)

E. Matějková1,2 , V. Foltánková2, I. Burešová3

1National Tissue Centre, Brno, Czech Republic

2Faculty of Science, 3University Cell Immunotherapy Centre, Masaryk University, Brno, Czech Republic

Pages: 146 - 153 (PDF)

 

Corresponding author: Eva Matějková, National Tissue Centre, Palachovo náměstí 2/726, 625 00, Brno, Czech Republic. Phone: (+420) 777 263 780; Fax: (+420) 511 180 700; e-mail: eva.matejkova@natic.cz

Original Article

Serum Levels of Matrix Metalloproteinases 2 and 9 and TGFBR2 Gene Screening in Patients with Ascending Aortic Dilatation

(aortic dilatation / MMP-2 / MMP-9 / TGFBR2)

J. Šímová1, J. Škvor2, J. Reissigová3, J. Dudra4, J. Lindner5, P. Čapek1,6, J. Zvárová3

1Department of Anthropology and Human Genetics, Faculty of Science, Charles University in Prague, Czech Republic

2Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University in Prague, Czech Republic

3European Centre of Medical Informatics, Statistics and Epidemiology, Department of Medical Informatics and Biostatistics, Institute of Computer Science AS CR, v. v. i., Prague, Czech Republic

4Educational and Research Institute AGEL – Centre for Applied Genomics, Czech Republic

52nd Department of Surgery – Department of Cardiovascular Surgery of the First Faculty of Medicine and General University Hospital in Prague, Czech Republic

6Institute of Criminalistics Prague, Department of Genetics, Police of the Czech Republic

Pages: 154 - 161 (PDF)

Corresponding author: Jana Šímová, Department of Anthropology and Human Genetics, Faculty of Science, Charles University in Prague, Viničná 7, 128 43, Prague 2, Czech Republic. E-mail:jsimova@centrum.cz

 

Original Article

Inhibition of mTORC1 by SU6656, the Selective Src Kinase Inhibitor, Is Not Accompanied by Activation of Akt/PKB Signalling in Melanoma Cells

(mTORC1 signalling / Src activity / Akt/PKB / raptor / rictor / HBL melanoma cells)

L. Ondrušová, J. Réda, P. Žáková, Z. Tuháčková

Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic

Pages: 162 - 167 (PDF)

Corresponding author: Zdena Tuháčková, Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Kateřinská 32, 121 08 Prague 2, Czech Republic. Phone: (+420) 723 938 384; e-mail: tuhack@img.cas.cz

 

Short Communication

Tagging rs10811661 Variant at CDKN2A/2B Locus Is Not Associated with Type 2 Diabetes Mellitus in Czech Population

(polymorphism / diabetes / Czech population / CDKN2A/2B)

J. A. Hubáček1, T. Neškudla2, M. Klementová2, V. Adámková3, T. Pelikánová2

Institute for Clinical and Experimental Medicine, 1Centre for Experimental Medicine, 2Diabetes Centre, 3Department of Preventive Cardiology, Prague, Czech Republic.

Pages: 168 - 171 (PDF)

 

Corresponding author: Jaroslav A. Hubáček, IKEM-DEM-LMG, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic. Phone: (+420) 261 363 379; Fax: (+420) 241 721 666; e-mail: jahb@ikem.cz