Volume 60 (2014) No. 5
Original Article
Towards Dissecting Molecular Routes of Intercellular Communication in the Tumour Microenvironment: Phenotypic Plasticity of Stem Cell-Associated Markers in Co-culture (Carcinoma Cell/Fibroblast) Systems
(cancer-associated fibroblasts / cancer stem cell / CD44 / galectin / side population / tumour stroma)
Z. Fík1,2, B. Dvořánková1, O. Kodet1,3, J. Bouček2,4, J. A. Betka2,4, J. Betka2, S. André5, H.-J. Gabius5, P. Šnajdr1, K. Smetana Jr.1, M. Chovanec1,2
1Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Czech Republic
2Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine and University Hospital Motol, Charles University in Prague, Czech Republic
3Department of Dermatology and Venereology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Czech Republic
4Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic v. v. i., Prague, Czech Republic
5Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany
Pages: 205 - 212 (PDF)
Corresponding author: Martin Chovanec, Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine and University Hospital Motol, Charles University in Prague, V Úvalu 84, 150 06 Prague 5, Czech Republic. E-mail: Martin.Chovanec@lf1.cuni.cz
Original Article
SKOV-3 and Me45 Cell Response to Cisplatin-Based Chemotherapy: an in Vitro Study
(ovarian cancer / melanoma / cisplatin / heat-shock proteins / glutathione S-transferase π / p53)
A. Gonera1, J. Wawryka1, A. Sobkowicz1, K. Biezunska-Kusiak2, M. Dubinska-Magiera4, A. Krajewski3, A. Choromanska2
1Faculty of Medicine, Student Scientific Circle of the 2Department of Medical Biochemistry, 3Second Department and Clinic of General and Oncological Surgery, Wroclaw Medical University, Wroclaw, Poland
4Department of Animal Developmental Biology, University of Wroclaw, Wroclaw, Poland
Pages: 213 - 219 (PDF)
Corresponding author: Anna Choromanska, Department of Medical Biochemistry, Wroclaw Medical University, Chalubinskiego 10, 50-368 Wroclaw, Poland. Phone: (+48) 71 784 18 87; Fax: (+48) 71 784 00 85; e-mail: awawrzuta@gmail.com
Original Article
Egg Yolk Phospholipids Enriched with 1-O-Octadecyl-2-Oleoyl-sn-Glycero-3-Phospho-(N-Palmitoyl) Ethanolamine Inhibit Development of Experimentally Induced Tumours
(hen egg phospholipids / phospholipid derivative NAEPE / inhibition of tumour cells / inhibition of liver / lung / kidney tumours / chicken model)
V. Karafiát, P. Veselý, M. Dvořák
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, v. v. i., Prague, Czech Republic
Pages: 220 - 227 (PDF)
Corresponding author: Michal Dvořák, Institute of Molecular Genetics AS CR, v. v. i., Vídeňská 1083, 142 20 Prague 4, Czech Republic. Phone: (+420) 296 443 390; Fax: (+420) 296 443 586; e-mail: mdvorak@img.cas.cz
Original Article
Mycophenolate Mofetil and Cyclophosphamide Treatments Suppress Inflammation Intensity in an Experimental Model of Autoimmune Uveitis
(experimental autoimmune uveitis / autoimmunity / retinal antigen / uveitis / uveoretinitis / mouse / mycophenolate mofetil / cyclophosphamide / golimumab)
A. Klímová1, P. Seidler Štangová1, J. Heissigerová1, P. Svozílková1, T. Kučera2
1Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
2Institute of Histology and Embryology, First Faculty of Medicine, Charles University in Prague, Czech Republic
Pages: 228 - 234 (PDF)
Corresponding author: Aneta Klímová, Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U nemocnice 2, 128 08 Prague 2, Czech Republic. e-mail: aneta.klimova@volny.cz
Original Article
Lipoprotein Lipase Deficiency: Clinical, Biochemical and Molecular Characteristics in Three Patients with Novel Mutations in the LPL Gene
(lipoprotein lipase deficiency / hypertriglyceridaemia / hypercholesterolaemia / hepatosplenomegaly / acute pancreatitis / lipaemia retinalis)
H. Kolářová1, M. Tesařová1, Š. Švecová1, V. Stránecký2, A. Přistoupilová2, T. Zima3, J. Uhrová3, S. Y. Volgina4, J. Zeman1, T. Honzík1
1Department of Paediatrics and Adolescent Medicine, 2Institute of Inherited Metabolic Disorders, 3Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
4Kazan State Medical University, Kazan, Russia
Pages: 235 - 243 (PDF)
Corresponding author: Tomáš Honzík, Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 2, 128 08 Prague 2, Czech Republic. Phone: (+420) 224 967 792; fax: (+420) 224 967 713; e-mail: tomas.honzik@vfn.cz
Original Article
Does Folic Acid Supplementation Rescue Defects in ECE-1-Deficient Mouse Embryos?
(endothelin-converting enzyme / mice / endothelin 1 / cardiac malformations / endothelin receptor)
A. Haque1, B. Šaňková1,2, A. Kvasilová1, E. Krejčí1,2, D. Sedmera1,2
1Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Czech Republic
2Department of Cardiovascular Morphogenesis, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Pages: 243 - 251 (PDF)
Corresponding author: David Sedmera, Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, U Nemocnice 3, 128 00, Prague 2, Czech Republic. Phone: (+420) 224 965 941; Fax: (+420) 224 965 770; e-mail: david.sedmera@lf1.cuni.cz
