Volume 65 (2019) No. 5-6
Original Article
Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins
(Caenorhabditis elegans / GPF-TRAP / interactome / Head module / mass spectrometry / Mediator complex
/ MED28 / MDT-28 / proteomic)
P. YILMA1, M. KOSTROUCHOVÁ1,2,*, P. TALACKO3, V. KOSTROUCHOVÁ1, D. KOSTROUCH1, P. NOVÁK4, M. KOSTROUCHOVÁ1,#
1Biocev, First Faculty of Medicine, Charles University, Vestec, Czech Republic
2Department of Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
3Laboratory of Mass Spectrometry, Faculty of Science, Charles University, Vestec, Czech Republic
4Biocev, Laboratory of Structural Biology and Cell Signalling, Institute of Microbiology of the Czech
Academy of Sciences, Prague, Czech Republic
Pages: 203 - 211 (PDF)
Corresponding author: Marta Kostrouchová, Biocev, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic. E-mail: marta.kostrouchova@lf1.cuni.cz
Original Article
Machine Learning and Deep Learning Approaches in Breast Cancer Survival Prediction Using Clinical Data
(breast cancer / survival prediction / deep learning / machine learning)
E. Y. KALAFI1, N. A. M. NOR1, N. A. TAIB2, M. D. GANGGAYAH1, C. TOWN3, S. K. DHILLON1
1Data Science and Bioinformatics Laboratory, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
2Department of Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia
3Computer Laboratory, University of Cambridge, Cambridge, United Kingdom
Pages: 212 - 220 (PDF)
Corresponding author: Sarinder Kaur Dhillon, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. Phone: (+603) 79676741; Fax: (+603) 79674178; e-mail: sarinder@um.edu.my
Original Article
Maternal Allergy Status Has No Impact on Neonatal Immune Responses to Allergen Stimuli
(allergy / allergen / cytokine / cord blood / gene expression)
A. LOHONKOVÁ1, O. NOVOTNÁ1, P. PETRÁSKOVÁ1, K. BORÁKOVÁ2, L. PROKEŠOVÁ1, J. HRDÝ1
1Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague,
Czech Republic
2Institute for the Care of Mother and Child, Prague, Czech Republic
Pages: 221 - 226 (PDF)
Corresponding author: Jiří Hrdý, Institute of Immunology and Microbiology First Faculty of Medicine, Charles University, Studničkova 7, 128 00 Prague 2, Czech Republic. Phone: (+420) 224 968 473; e-mail: jiri.hrdy@lf1.cuni.cz. Orcid number: 0000-0003-0612-4509
Original Article
Matrix Metalloproteinases and Their Tissue Inhibitors: an Evaluation of Novel Biomarkers in ANCA-Associated Vasculitis
(anti-neutrophil cytoplasmic antibodies / vasculitis / matrix metalloproteinases / tissue inhibitors of
metalloproteinases / pregnancy-associated plasma protein A)
O. ZAKIYANOV1, Z. CHOCOVÁ1, Z. HRUŠKOVÁ1,2, Z. HLADINOVÁ1, M. KALOUSOVÁ3, K. MALIČKOVÁ3, V. BEDNÁŘOVÁ1, J. VACHEK1, P. WURMOVÁ1, V. KŘÍHA4, T. ZIMA3, V. TESAŘ1
1Department of Nephrology, 3Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
2Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague,
Czech Republic
4Institute of Radiation Oncology, Bulovka Hospital, Prague, Czech Republic
Pages: 227 - 236 (PDF)
Corresponding author: Oskar Zakiyanov, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 00 Prague 2, Czech Republic. Phone: (+420) 22496 2673; Fax: (+420) 22496 2696; e-mails: oskar.zakiyanov@lf1.cuni.cz; oskar.zakiyanov@vfn.cz
Original Article
Peroxynitrite-Induced Intracellular Ca2+ Depression in Cardiac Myocytes: Role of Sarco/Endoplasmic Reticulum Ca2+ Pump
(intracellular Ca2+ / SERCA2a / myocytes / peroxynitrite)
V. FLORES-TAMEZ1, B. ESCALANTE1,2, A. RIOS1
1Centro de Investigación y de Estudios Avanzados del IPN, Unidad-Monterrey, PIIT, Apodaca NL, México
2Universidad de Monterrey, San Pedro Garza García, NL, México
Pages: 237 - 245 (PDF)
Corresponding author: QFB. Amelia Rios, Cinvestav Monterrey, Vía del Conocimiento, 201 66600 Apodaca, NL, México. Phone: (+52) 81 11561740; e-mail: arios@cinvestav.mx
Original Article
γ-Aminobutyric Acid (GABA) Induced in Vitro Differentiation of Rat Pancreatic Ductal Stem Cells into Insulin-Secreting Islet-Like Cell Clusters
(γ-aminobutyric acid / pancreatic ductal stem cells / differentiation / insulin-secreting cells)
M. W. GHANI, Z. YI, W. JIANG, L. YE, L. BIN, L. G. CUN, M. W. BIRMANI, X. MEI
Department of Animal Breeding, Genetics and Reproduction, Guangdong Ocean University, Zhanjiang,
Guangdong, China
Pages: 246 - 255 (PDF)
Corresponding author: Xiao Mei, Department of Animal Breeding, Genetics and Reproduction, Guangdong Ocean University, Zhanjiang, Guangdong, China. Phone: (+86) 13380912970, e-mail:
xiao0812@126.com
Original Article
New Developments in Understanding the Histological Structure of Human Ear Cartilage
(auricular cartilage / layered arrangement of chondrocytes / immunophenotype of chondrocytes/ maintenance of fixed shape of the pinna)
M. KAŇA1, R. KAŇA2, C. POVÝŠIL3
1Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
2Department of Otorhinolaryngology, General University Hospital, Prague, Czech Republic
3Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital,
Prague, Czech Republic
Pages: 256 - 264 (PDF)
Corresponding author: Ctibor Povýšil, Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital, Studničkova 2, 128 00 Praha 2, Czech Republic. Phone: (+420) 224 968 660; e-mail: ctibor.povysil@lf1.cuni.cz
Original Article
Metronidazole Attenuates the Intensity of Inflammation in Experimental Autoimmune Uveitis
(experimental autoimmune uveitis / uveitis / antibiotics / microbiome / metronidazole / ciprofloxacin)
P. SEIDLER STANGOVA1, O. DUSEK1, A. KLIMOVA1, J. HEISSIGEROVA1, T. KUCERA2, P. SVOZILKOVA1
1Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
2Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic
Pages: 265 - 274 (PDF)
Corresponding author: Petra Svozilkova, Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic. E-mail: petra.svozilkova@lf1.cuni.cz
Original Article
Effect of Graviola (Annona Muricata l.) and Ginger (Zingiber Officinale Roscoe) on Diabetes Mellitus Induced in Male Wistar Albino Rats
(diabetes mellitus / glucose transporters / insulin resistance / glycosylated haemoglobin / Annona / ginger)
K. M. AL SYAAD1, F. G. ELSAID1,2, M. E. ABDRABOH2, A. A. AL-DOAISS1,3
1Biology Department, College of Science, King Khalid University, Abha, Saudi Arabia
2Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt
3Anatomy and Histology Department, Faculty of Medicine, Sana’a University, Sana’a, Republic of Yemen
Pages: 275 - 284 (PDF)
Corresponding author: Fahmy G. Elsaid, Biology Department, College of Science, King Khalid University, KSA; Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt. E-mail: felsaid@kku.edu.sa
