Volume 66 (2020) No. 1
Original Article
Hereditary Haemorrhagic Telangiectasia (HHT) Marked by ACVRL1C1120T Variant Displays Hypopigmented Naevi and Frequent Bleeding Episodes if CYP2C9 Co-Mutated: Clinical Notes & Rationale of Patient Registry
(hereditary haemorrhagic telangiectasia / personalized medicine / whole exome sequencing / NGS / hereditary diseases / haemorrhage)
L. MINARIK1, 2, K. VARGOVA3, N. DUSILKOVA1,3, V. KULVAIT1, A. JONASOVA2, O. KODET4, T. STOPKA1, 2
1Biocev, First Faculty of Medicine, Charles University, Vestec, Czech Republic
2First Department of Medicine, Department of Haematology, 4Department of Dermatology and Venereology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
3Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
Pages: 1 - 6 (PDF)
Corresponding author: Tomas Stopka, Průmyslová 595, 252 42 Vestec, Czech Republic. Phone: (+420) 32587 3001; e-mail: tstopka@lf1.cuni.cz
Original Article
Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma
(melanoma / mutation / deletion / loss of expression / PTEN)
K. NĚMEJCOVÁ1, P. DUNDR1, R. JAKŠA1, M. BÁRTŮ1, I. Stružinská1, J. HOJNÝ1, N. HÁJKOVÁ1, O. KODET2,3
1Institute of Pathology, 2Department of Dermatology and Venereology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
3Institute of Anatomy, First Faculty of Medicine, Charles University, Czech Republic.
Pages: 7 - 16 (PDF)
Corresponding author: Kristýna Němejcová, Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, 128 00, Prague 2, Czech Republic. E-mail: kristyna.nemejcova@vfn.cz
Original Article
Anti-CD38 Therapy with Daratumumab for Relapsed/ Refractory CD20-Negative Diffuse Large B-Cell Lymphoma
(Non-Hodgkin lymphomas / CD38 / daratumumab / patient-derived xenograft)
P. VOCKOVA1,2, M. SVATON3, J. KAROLOVA1,2, E. POKORNA1, M. VOKURKA1, P. KLENER1,2
1Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
21st Department of Medicine – Department of Haematology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
3CLIP – Laboratory Centre Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
Pages: 17 - 23 (PDF)
Corresponding author: Pavel Klener, Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic, and 1st Department of Medicine – Department of Haematology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 5, 128 53 Prague 2, Czech Republic. Phone: (+420) 224 965 930; e-mail: pavel.klener2@lf1.cuni.cz
Martin Vokurka, Institute of Pathological Physiology, First Faculty of Medicine, Charles University, U Nemocnice 5, 128 53 Prague 2, Czech Republic. Phone: (+420) 224 965 928; e-mail: martin.vokurka@lf1.cuni.cz
Original Article
Domination of Filamentous Anoxygenic Phototrophic Bacteria and Prediction of Metabolic Pathways in Microbial Mats from the Hot Springs of Al Aridhah
(microbial mats / hot springs / 16S amplicon / Chloroflexus / Saudi Arabia)
M. YASIR1,5, A. K. QURESHI1, S. SRINIVASAN2, R. ULLAH1, F. BIBI1,5, M. REHAN3,5, S. B. KHAN4, E. I. AZHAR1,5
1Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah,
Saudi Arabia
2Institute of Bioinformatics and Applied Biotechnology, Bangalore, Karnataka-560100, India
3King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
4Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia
5Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Pages: 24 - 35 (PDF)
Corresponding author: Corresponding author: Muhammad Yasir, Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah-21589, Saudi Arabia. E-mail: yasirkhattak.mrl@gmail.com
Original Article
Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
(ovarian / cancer / kaempferol / apoptosis / cisplatin)
A. F. EL-KOTT1,2, A. A. SHATI1, M. A. AL-KAHTANI1, S. A. ALHARBI3
1Biology Department, College of Science, King Khalid University, Abha, Saudi Arabia
2Zoology Department, College of Science, Damanhour University, Damanhour, Egypt
3Department of Physiology, College of Medicine, Umm Al-Qura University, Mekkah, Saudi Arabia
Pages: 36 - 46 (PDF)
Corresponding author: Attalla Farag El-kott, College of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia. Phone: (+966) 508748239; e-mails: elkottaf@yahoo.com; elkottaf@kku.edu.sa
