Volume 66 (2020) No. 4
Original Article
PD-1, PD-L1 and PD-L2 Expression in Mantle Cell Lymphoma and Healthy Population
(mantle cell lymphoma / PD-1 / PD-L1 / PD-L2 / B cells / T cells/ immunosenescence)
J. KAROLOVA1, 2, M. RADEK2, 4, K. HELMAN3, M. SPACEK2, 4, M. TRNENY2, P. KLENER1, 2
1Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
21st Department of Medicine, Department of Haematology, 4Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
3Faculty of Informatics and Statistics, University of Economics, Prague, Czech Republic
Pages: 117 - 122 (PDF)
Corresponding author: Pavel Klener, Institute of Pathological Physiology, First Faculty of Medicine, Charles University, U Nemocnice 478/5, 128 00 Prague, Czech Republic, Phone: (+420) 224 965 933, (+420) 224 965 929; e-mail: pavel.klener2@lf1.cuni.cz.
Original Article
Phenotype Variability in Czech Patients Carrying PAX6 Disease-Causing Variants
(aniridia / ptosis / congenital cataract / uveal coloboma / PAX6 / novel variant / exon trapping)
J. MORAVIKOVA1, Z. KOZMIK2, L. HLAVATA1, M. PUTZOVA3, P. SKALICKA1,4, M. MICHAELIDES5,6, F. MALINKA1,7, L. DUDAKOVA1, P. LISKOVA1,4
1Research Unit for Rare Diseases, Department of Paediatrics and Inherited Metabolic Disorders, 4Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
2Department of Transcriptional Regulation, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic
3Biopticka laborator s.r.o., Pilsen, Czech Republic
5UCL Institute of Ophthalmology, University College London, London, UK
6Moorfields Eye Hospital NHS Foundation Trust, London, UK
7Department of Computer Science, Czech Technical University in Prague, Czech Republic
Pages: 123 - 132 (PDF)
Corresponding author: Lubica Dudakova, Research Unit for Rare Diseases, Department of Paediatrics and Inherited Metabolic Disorders, Ke Karlovu 455/2, 128 08 Prague 2, Czech Republic. e-mail: lubica.dudakova@lf1.cuni.cz.
Original Article
The Von Willebrand Factor Antigen Plasma Concentration: a Monitoring Marker in the Treatment of Aortic and Mitral Valve Diseases
(von Willebrand factor / aortic valve stenosis / vWF multimers / valvular disease / coagulation / mitral valve regurgitation)
M. A. PERRONE1#, F. G. VIOLA2#, M. MINIERI2,3, S. CAPORALI4, A. COPPONI2, G. SANCESARIO2, S. ANGELETTI5, R. MASSOUD2,3, F. ROMEO1,2, S. BERNARDINI2,3*, A. TERRINONI3*
1Department of Systems Medicine, 3Department of Experimental Medicine, 4Department of Industrial Engineering, University of Rome Tor Vergata, Rome, Italy
2Unit of Laboratory Medicine, Policlinico Tor Vergata, Rome, Italy
5Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy
Pages: 133 - 141 (PDF)
Corresponding author: Alessandro Terrinoni and Sergio Bernardini, Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier, 1. 00133 Rome, Italy. E-mails: alessandro. terrinoni@uniroma2.it – bernards@uniroma2.it
Short Communication
Genistein Induces Bcl-2 Expression in Human Dermal Microvascular Endothelial Cells: a Short Report
(wound healing / angiogenesis / hormone replacement therapy / phytoestrogen)
V. Lachová1, P. Mitrengová1, N. MELEGOVÁ2,3, K. SMETANA JR.4,5, P. Gál3,6,7
1Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
2Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovak Republic
3Laboratory of Cell Interactions, Center of Clinical and Preclinical Research MediPark, Pavol Jozef Šafárik University, Košice, Slovak Republic
4Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic
5BIOCEV, Vestec, Czech Republic
6Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Košice, Slovak Republic
7Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
Pages: 142 - 147 (PDF)
Corresponding author: Peter Gál, East-Slovak Institute of Cardiovascular Diseases and P. J. Šafárik University (Center of Clinical and Preclinical Research MediPark), Trieda SNP 1, 040 11 Košice, Slovak Republic. Fax: (+421) 55 789 1610; e-mail: galovci@yahoo.com or pgal@vusch.sk
Short Communication
Genetic Markers at ANRIL, FTO and 2q36.3 Locus in Czech Patients Undergoing Coronary Artery Bypass Graft Surgery
(polymorphism / FTO / ANRIL / 2q36.3 locus / coronary artery bypass surgery)
P. KAČER1,2, J. PIRK2, V. LÁNSKÁ3, J. A. HUBÁČEK4, V. ADÁMEK5, T. ČERVINKOVÁ5, J. BĚLOHOUBEK5, O. AUZKÝ5, V. ADÁMKOVÁ5
¹Department of Cardiac Surgery, Královské Vinohrady University Hospital in Prague, Third Faculty of Medicine, Charles University, Prague, Czech Republic
2Cardiocentre; 3Medical Statistics Unit; 4Centre for Experimental Medicine; 5Department of Preventive Cardiology; Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Pages: 148 - 153 (PDF)
Corresponding author: Petr Kačer, Third Faculty of Medicine, Charles University, Ruská 87, 100 00, Prague 10, Czech Republic. E-mail: petr.kačer@lf3.cuni.cz
