Volume 67 (2021) No. 2

Original Article

Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy-Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway

(ghrelin / gastrectomy / Tau / hippocampus / Alzheimer’s disease)

M. D. Morsy1, M. A. ALsaleem2, M. S. Aboonq3, S. O. Bashir1, H. A. Al-Daher1

1Department of Physiology, 2Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia

3Department of Physiology, College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

Pages: 49 - 69 (PDF)

Corresponding author: Mohamed Darwesh Morsy, Department of Physiology, College of Medicine, King Khalid University, 61421 Abha, Saudi Arabia. Phone: +966 544 495 223; Fax: +966 172 251 690; e-mail: morsydarwesh@yahoo.com


Original Article

Not Only Hypoxia- but Radiation-Induced Epithelial-Mesenchymal Transition Is Modulated by Hypoxia-Inducible Factor 1 in A549 Lung Cancer Cells

(epithelial-mesenchymal transition / HIF-1α / HIF-1α inhibitor / JNK / E-cadherin / vimentin)

M. SATO1, 2, 3, K. HIROSE1, 2, 3, K. ICHISE1, H. YOSHINO4, T. HARADA2, Y. HATAYAMA1, H. KAWAGUCHI1, M. TANAKA1, I. FUJIOKA1, Y. TAKAI2, 3, M. AOKI1

1Department of Radiation Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Japan

2Southern Tohoku BNCT Research Center, Yatsuyamada, Koriyama, Japan

3Department of Radiation Oncology, Southern Tohoku General Hospital, Yatsuyamada, Koriyama, Japan

4Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hon-cho, Hirosaki, Japan

Pages: 62 - 69 (PDF)

Corresponding author: Katsumi Hirose, Department of Radiation Oncology, Southern Tohoku BNCT Research Center, 7-10 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan. Phone & Fax: (+81) 24-934-5322; e-mail: khirose@hirosaki-u.ac.jp


Short Communication

The Morphology of Cell Differentiation, Terminal Differentiation and Ageing Seems To Reflect the Same Process: a Short Note

(differentiation and ageing / morphology / human granulocytic and erythroid cell lineages)

K. SMETANA, D. MIKULENKOVÁ, H. KLAMOVÁ

Institute of Haematology and Blood Transfusion, Prague, Czech Republic

Pages: 70 - 75 (PDF)

Corresponding author: Karel Smetana, Institute of Haematology and Blood Transfusion, U nemocnice 1, 128 20 Prague 2, Czech Republic. E-mail: karel.smetana@uhkt.cz


Short Communication

Human Adrenocortical Carcinoma (NCI-H295R) Cell Line as an In Vitro Cell Culture Model for Assessing the Impact of Iron on Steroidogenesis

(NCI-H295R cell line / ferrous sulphate heptahydrate / endocrine disruption / sexual steroid hormones / cell viability)

Z. KŇAŽICKÁ1, V. FIALKOVÁ2*, H. ĎÚRANOVÁ2, J. BILČÍKOVÁ2,3, E. KOVÁČIKOVÁ2, M. MIŠKEJE2, V. VALKOVÁ2, Z. FORGÁCS4, S. ROYCHOUDHURY5, P. MASSÁNYI6, N. LUKÁČ6

Pages: 76 - 81 (PDF)

Corresponding author: Veronika Fialková, AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, Tr. Andreja Hlinku 2, 949 76 Nitra, Slovak Republic. Phone: (+421) 376 414 926; e-mail: veronika.fialkova@uniag.sk


Short Communications

A Preliminary Characterization of a Novel Recombinant Clostridial Collagenase Blend

(collagenase / recombinant / Escherichia coli)

I. LEONTOVYC1, T. KOBLAS1, Z. BERKOVA1, K. BITTENGLOVA2,3, A. LEONTOVYC4, M. BENESIK5, F. SAUDEK2

1Laboratory for the Islets of Langerhans, Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

2Department of Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

3Department of Biomedicine – Cell Biology and Pathology, First Faculty of Medicine, Charles University, Prague, Czech Republic

4Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic

5Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic

Pages: 82 - 89 (PDF)

Corresponding author: Ivan Leontovyč, Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic. E-mail: ivan.leontovyc@ikem.cz